Scientist II, Analytical Development

At Insmed, every moment and every patient counts - and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About the Role:
We're looking for a Scientist II on the Analytical Development team to help us expand what's possible for patients with serious diseases. Reporting to the Senior Scientist, Analytical Development, you'll be part of a multidisciplinary team of scientists focused on the analytical procedure development and characterization of ground-breaking gene therapies. You will author and execute phase appropriate qualification/validation protocols and reports of AD/QC methods to support product release and characterization.

What You'll Do:

In this role, you'll have the opportunity to develop, improve, implement, transfer and co-validate robust vector genome titer assays with a receiving laboratory (QC internal/external). Your work will also encompass the development of NGS sample preparation methods and the operation of both short read (Element) and long read (PacBio) NGS instruments to characterize AAV drug products, cell lines, and other R&D and CMC samples. You may also be involved in supporting process development activities with potency assay testing and participate in CMC team and governance team activities as needed. You'll also:

• Serve as a subject-matter-expert for vg titer, NGS assays and data interpretation.
• Execute protocols to qualify/validate vg titer assays and characterize AAV drug products and potency assay cell lines.
• Write and review methods, protocols, reports and other product development documents to support filings (INDs/BLAs) and regulatory interactions (briefing books, etc). Will act as a SME during interactions with health authorities as needed.
• Define and implement state-of-the art PCR and NGS sequencing technologies for characterizing all facets of our drug products.
• Design, execute and troubleshoot Next-Generation Sequencing (NGS) assays including nucleic acid (DNA/RNA) purification and library preparation for various sequencing applications including Whole- Genome Sequencing (WGS), Whole-Exome Sequencing (WES), RNA-sequencing, target-enrichment, amplicon sequencing and custom workflows.
• Work with the bioinformatics team to develop and improve tools and pipelines.
• Operate, maintain, and troubleshoot short read (Element) and long read (PacBio) sequencing platforms.
• Maintain accurate, detailed, and timely records of analytical procedure development, experimental data, and data analysis utilizing an electronic lab notebook.
• Perform data review to ensure accuracy, completeness, and validity.
• Participate in cross-disciplinary mentoring and training of associate scientists.
• Present scientific results to the larger Insmed research and technical operations groups, and external scientific community, as needed.

Who You Are:

You have a Bachelor's degree in Molecular Biology, Biochemistry, or a related field with 5+ years of relevant scientific or industry experience; or Master's degree with 3+ years; or PhD with 1+ year of experience

You are or you also have:

• Strong experience with nucleic acid sample preparation, primer/probe design, qPCR/ddPCR, and NGS
• Experience developing, optimizing, and troubleshooting short- and long-read sequencing methods
• Demonstrated success in method development, including experimental design, execution, and evaluation
• Hands-on experience with routine protein characterization techniques such as spectroscopy, SDS-PAGE, western blot, ELISA, and capillary electrophoresis
• Experience using JMP or equivalent statistical software for data analysis, assay control charts, and assay acceptance criteria
• Excellent written and verbal communication skills
• Highly organized with strong attention to detail, clarity, accuracy, and conciseness
• Strong analytical and problem-solving skills
• Ability to thrive in a dynamic work environment and a demonstrated commitment to diversity of individuals and ideas

Nice to have (but not required):

• Familiarity with commercial bioinformatics pipeline interfaces (e.g., GeneData)
• Experience in an FDA-regulated, pharmaceutical GMP testing environment

Where You'll Work

This role is based out of our San Diego office and requires full-time, in-person presence to support hands-on collaboration, access specialized equipment, and/or operational needs.

Travel Requirements

Minimal travel expected

#LI-POST

#LI-MC1

Pay Range:
$127,000.00-165,500.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at [email protected] and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.