Sr. Software Engineer

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

The Sr. Software Engineer will support the transformation and optimization of our Laboratory Information Management System (LIMS) and its integration with lab automation and broader data systems. This individual will play a key technical role in designing and developing robust, scalable software solutions that drive clinical and laboratory operations. Working cross-functionally with stakeholders across the organization from lab operations to finance, this role will contribute to the architecture, development, maintenance, and user support of the various in-house and 3rd party software, continuous delivery, and legacy system evolution.

This is a hands-on role ideal for an experienced engineer who thrives in fast-paced, regulated environments and is passionate about software quality, automation, and continuous improvement in the life sciences space.

Onsite: Monday, Tuesday, and Thursday

Responsibilities:

• Design, develop, and maintain integrated software solutions that drive efficiency and automation across laboratory processes.


• Collaborate with highly talented staff of diverse expertise to understand user needs, define technical requirements, and translate them into reliable and scalable software components.


• Contribute to the ongoing operation and support of clinical software systems, including legacy LIMS platforms and new software development initiatives.


• Implement CI/CD pipelines, perform code reviews, write unit/integration tests, and ensure software is deployed and maintained with high quality and traceability.


• Support 24/7 laboratory operations through participation in site reliability engineering efforts.


• Develop technical documentation, including data mappings, functional specifications, and system architecture overviews.


• Collaborate with QA and compliance teams to ensure software is developed in alignment with CAP/CLIA regulations and internal quality standards.


• Actively contribute to a culture of engineering excellence through mentorship, knowledge sharing, and advocacy for best practices in software engineering.

Requirements:

• B.S. degree or equivalent combination of education and experience in Computer Science, Bioinformatics, Engineering or relevant qualification.


• 5+ years of experience in software engineering, site reliability engineering, and/or devops.


• 2+ years of life sciences domain experience and laboratory software experience, such as Clarity, Lab Vantage, or other laboratory information management systems.


• Expertise in full-stack software engineering technologies: Python, Java, PostgreSQL, MySQL, web frameworks such as Flask and Django, Linux and Windows Operating Systems, CI/CD, and best Practices.


• Experience working in CAP/CLIA environments and utilizing version control and documentation as managerial tools.


• Strong communication skills, written and verbal; ability to understand user needs and present architectures and their implications in a clear, concise manner.


• A deep understanding of software engineering principles and practices.

The hiring range for this position is $146,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

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