Senior Staff Engineer, Machine Learning (24215-U-670-CBIO)

Arsenal Biosciences
South San Francisco, CA

WHO WE ARE

Arsenal Biosciences Inc. is a clinical-stage programmable cell therapy company engineering advanced CAR T-cell therapies for solid tumors. We are seeking a talented Principal Engineer, Computational Biology and Machine Learning to work hybrid based in our South San Francisco office.

ArsenalBio’s mission and purpose is very clear: defeat cancer. With our programmable and computationally driven approach, our team is engineering medicines with the goal to attack cancer’s inherent multifaceted nature and overcome the challenges of addressing solid tumors with cell therapy.

Driven by a collective of diverse experts across multi-scientific disciplines as well as clinical and manufacturing expertise, we are united in our purpose to develop the optimal medicines for improving patients’ lives.

Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, machine learning and AI, automation, genome engineering, software and other fields to make the future happen now.

This means you’ll have the opportunity to work with the best talent in the field of cell therapy, and be part of ONE TEAM advancing therapies for patients who need it most.

ArsenalBio is looking for a founding Senior Staff Machine Learning Engineer to lead the charge in creating our AI platform! As our very first ML engineering hire, you’ll have the unique opportunity to build our ML infrastructure from scratch, shape our technical strategy, and assemble a top-tier engineering team that powers AI-driven drug discovery. This is more than a job—it’s a chance to apply groundbreaking AI methods to revolutionize medicine, making a direct, meaningful impact on patients' lives. If you're excited to push the boundaries of AI in healthcare, we want to hear from you!

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WHAT YOU’LL DO
  • Design and implement the foundational ML architecture to power our next generation of cell therapy discovery platforms. Profile machine learning workflows, identify bottlenecks, and implement solutions to increase efficiency and hardware utilization.
  • Define technical standards and establish MLOps practices for the organization, including experiment tracking, model versioning, and automated deployment pipelines
  • Implement MLOps solutions and integrations of our ML platforms with other software systems.
  • Collaborate with product, design, front-end, machine learning, and infrastructure teams.
  • Train and mentor fellow ML engineers.

WHO YOU ARE
  • Masters with 5+ years of relevant experience; or Bachelors with 7+ years of relevant experience
  • Proven track record of architecting production ML systems from scratch, with experience making strategic technical decisions that impact organization-wide ML capabilities
  • Experience implementing, extending, and debugging state-of-the-art machine learning models, and have expertise in designing and building robust data infrastructure and tools
  • Experience in applying deep learning to model biological data
  • Strong software engineering skills and substantial expertise in Python
  • Ability to work collaboratively and communicate effectively in an interdisciplinary environment

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BENEFITS AND PAY

ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge.

Our people-first culture fosters a deep appreciation for humanity, both in the people we endeavor to serve as well as each other. We are proud to work for a company that is driven by diversity in experiences, ideas and interests, and one that empowers us in an environment that embraces both unity and inclusivity.

We have robust tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as our people are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

The estimated base salary for the preferred primary location of the San Francisco Bay area ranges from $240,000- $260,000. Salary ranges for other locations may vary. Base pay offered may vary based on job related knowledge, experience, education, and location. In addition to these factors, we believe in the importance of pay equity and consider internal equity of our current employees as part of any final offer.

To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

Posted 2025-09-22

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