Scientist I/II, Biologics Cell Line Development

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok .

Job Description

The Cell Line Development Group in South San Francisco, CA is seeking an Scientist I or Scientist II to join a talented and collaborative team developing CHO cell lines for GMP applications. In this laboratory position the candidate will perform hands-on CHO cell line development and characterization studies in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. The work will encompass cellular and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our pipeline candidates.

• Perform CHO cell line development, including transfection, selection, single cell subcloning, growth and productivity screening, cell banking and stability assessment of cell banks.
• Culture mammalian cells across multiple scales and formats, from 96-well plates up to shake flasks.
• Operate instruments like ViCell automated cell counter, Octet, Clone Select Imager, microscope, HPLC, ambr15, Beacon, flow cytometer and Liquid handlers (Tecan and Hamilton). Share responsibility for equipment maintenance.
• Author and review cell line development technical reports that meet expectations of regulatory agencies for all stages from IND to BLA.
• Present updates at cross-functional meetings and collaborate closely with cell culture, purification, analytical and formulation development colleagues to meet project timelines.
• Actively seek opportunities to optimize or enhance the cell line development workflow.
• May publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia.
• Display effective organization, verbal and written communication skills, and adherence to good documentation practices.

Qualifications

Basic:

• Scientist I: Bachelor’s Degree or equivalent education with typically 5 years of experience, or Master’s Degree or equivalent education with typically two years of experience.
• Scientist II: BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.
• Proficient in aseptic techniques and mammalian cell culture. Strong understanding of cell biology and bioprocess engineering concepts.
• Experienced in developing stably transfected CHO cell lines for production of monoclonal antibodies and antibody-like molecules.
• Experienced in operating liquid handlers like Tecan and Hamilton for automated, high throughput cell culture activities.
• Excellent attention to detail and must keep detailed records in electronic lab notebook on a daily basis.
• Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.
• Demonstrated ability to learn, understand and master new experimental techniques.
• Demonstrated ability to work collaboratively within and outside of the group.
• Demonstrated ability to author technical reports and presentations.
• Proficient with Microsoft Office software and able to learn new software applications.
• Able to multi-task and work within timelines.
• Strong communication skills – verbal, written, scientific data presentation.

Preferred:

• Exposure to CHO cell line development for GMP applications within biotech/pharma industry.
• Previous hands-on experience with Beacon, flow cytometry, ddPCR and ambr15 operation.
• Prior experience in evaluating, optimizing and establishing automated, high throughput cell culture workflows using liquid handlers like Tecan and Hamilton.
• Proficiency in programming/data science languages, such as R, Python, and SQL. Prior experience performing statistical analysis and visualization using JMP, SIMCA, Spotfire and Power BI.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements understate or local law: ​​​

• This is an on-site position located in AbbVie's South San Francisco location.
• The compensation range described below is the range of possible base pay compensation that theCompany believes in good faith it will pay for this role at the time of this posting based on the job gradefor this position. Individual compensation paid within this range will depend on many factors includinggeographic location, and we may ultimately pay more or less than the posted range. This range may bemodified in the future.​​
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/vision insurance and 401(k) to eligible employees.​​
• This job is eligible to participate in our short-term incentive programs. ​​​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested,and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any otherform of compensation and benefits that are allocable to a particular employee remains in the Company'ssole and absolute discretion unless and until paid and may be modified at the Company’s sole andabsolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

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