Scientist, Protein Production and Characterization

Overview

Scientist, Protein Production and Characterization

AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

We are seeking a highly motivated and skilled Scientist to join our Protein Sciences team and contribute to both day-to-day operations and the advancement of Protein Science workflows. This position will focus on the design, optimization, and execution of transient transfection processes at various scales for antibody and protein production in mammalian expression systems. The successful candidate will leverage expertise in biophysical characterization and biochemical modification to evaluate key protein attributes. This position will report to the Associate Director of Protein Sciences and work closely with scientists in the Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management teams. The ideal candidate will drive innovation through process refinement, high-throughput automation, and growing proficiency of chemical conjugation techniques. This role offers the opportunity to work in a fast-paced, collaborative research environment, where creative solutions and a strong scientific approach are key to success.

Responsibilities

Responsibilities:

• Independently design, plan, and execute transient transfection workflows for antibody and protein production across various mammalian expression systems
• Develop, design, and optimize protein purification methods to enhance throughput, quality, and efficiency, as required
• Lead developability assessment studies by designing and conducting analytical experiments to evaluate protein stability, purity, and key biophysical characteristics
• Support production of complex construct design strategies (e.g VLPs, nanodiscs etc.), to enable immunization antibody discovery campaigns against challenging targets
• Drive implementation of automated high throughput processes to support protein production workflows using Bravo, and other robotic systems
• Maintain meticulous experimental records using electronic notebook (Benchling), and communicate results clearly through written reports and presentations to support project progression and scientific decision-making
• Contribute innovative ideas and collaborate effectively across teams to foster research excellence and ensure project success in a fast-paced environment

Qualifications

Qualifications:

• Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or a related field with a minimum of 2 years of industry experience or MS with minimum of 6 years of direct industry experience is required
• Proven hands-on experience with multiple mammalian expression platforms is required
• Proficiency with AKTA instrumentation, and a broad range of purification techniques, including affinity chromatography, ion exchange, HIC, and SEC, as well as standard protein QC methodologies is required

• Experience with therapeutic antibody developability assessment is highly desirable

• Strong analytical, troubleshooting, and communication skills with exceptional attention to detail
• Motivated self-starter with excellent organization, teamwork, and a passion for scientific innovation

About AlivaMab Biologics

AlivaMab Biologics sets its partners' antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners' design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multi-specifics and CARs. The AMB team's experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab® Mouse platforms, ensure the highest probability of success.

The salary range for this position considers various factors, including skills, experience, training, certifications, and organizational needs. Note that this range does not reflect any geographic adjustments based on the location where the role will be based. At AlivaMab Biologics, it is uncommon for a new hire to start at or near the top of the salary range, as compensation is tailored to each individual's skills and breadth and depth of experience. The current estimated range is $98,500 - $140,000, plus a bonus target, benefits, and equity.

AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

#LI-DNI