Senior DevSecOps / Infrastructure Engineer

Mandolin
San Francisco, CA

About Mandolin

Nearly all disease will become treatable in our lifetimes, and drug discovery is quickly becoming an engineering discipline. Mandolin is building the “last-mile” delivery infrastructure that gets cutting-edge biologics, cell, and gene therapies to patients faster. Our AI-powered knowledge-worker platform already serves leading infusion clinics, with payers and pharma next in line.

We’re backed by Greylock, SignalFire, Maverick, and founders of famous companies like Yahoo, and led by repeat and exited founders with a team hailing from some of the most technically impressive companies.

Why we need you

Mandolin’s usage is climbing quickly and we’re preparing for a broad public launch. The platform must deliver enterprise-grade reliability, airtight security, and effortless developer productivity while processing sensitive healthcare data. We’re looking for a DevSecOps leader who can build and operate a rock-solid cloud foundation—then codify the best-practice guardrails that every engineer will rely on as we scale.

What you’ll do

  • Design & own cloud infrastructure on GCP. Establish autoscaling policies, HA networking, and cost-efficient environments across staging and prod.

  • Implement comprehensive security controls. Centralize secrets management and rotation, define zero-trust IAM policies, and integrate continuous vulnerability scanning into CI/CD.

  • Stand up first-class observability. Deploy and maintain metrics, tracing, and log pipelines (Prometheus, Grafana, Cloud Logging, etc.), plus actionable SLOs and alerting.

  • Streamline developer experience. Provide dev-containers, local-env scripts, and clear runbooks that let new engineers ship safely on day one.

  • Embed security into the SDLC. Own IaC (Pulumi), automated compliance checks, and incident-response playbooks.

  • Collaborate across teams. Review architectural changes for security impact and partner with backend teams on scalability initiatives.

  • Scale the function. Optionally hire or mentor a junior engineer once the foundation is solid.

Must-have experience

  • 8 + years building and securing production cloud infrastructure, with deep GCP knowledge (Cloud Run, Cloud Build, IAM).

  • Expert with container orchestration and autoscaling strategies.

  • Proven record deploying centralized secrets management and automated rotation.

  • Ownership of observability stacks and incident-response pipelines.

  • Strong application-security background (OWASP, API gateway/WAF, dependency & image scanning).

  • Mastery of IaC (Terraform, Pulumi, or equivalent) and CI/CD (GitHub Actions, Cloud Build, GitLab CI, etc.).

  • Comfortable operating in a fast, results oriented, and scaling startup environment.

Nice-to-haves

  • Experience with workflow orchestration platforms (Temporal, Cadence, Airflow).

  • Prior work in HIPAA, SOC 2, or similarly regulated environments.

  • Exposure to edge-security patterns (zero-trust networking, service-mesh, mTLS).

  • Background building internal developer platforms or golden-path tooling.

Posted 2025-09-22

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