Scientist I

Target PR Range: 44-54/hr
*Depending on experience

General Position Summary/Purpose:

The Quantitative, Translational & ADME Sciences (QTAS) department is seeking a highly motivated fulltime contract Scientist to join the In Vitro ADME Sciences group (IVAS). The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and may work on other in vitro ADME assays. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.

In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes. Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

Core Job Responsibilities:

· Routinely conduct (hands-on) evaluation of CYP450 induction

· Conduct qPCR assay

· Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems

· Perform human and rodent hepatocytes cell culture, seeding and maintenance

· Perform cell viability assessments and use microplate reader to measure endpoints

· Contribute to the design of invitro ADME assays and data interpretation

· Analyze data and maintain detailed, accurate and comprehensible study documentations

· Use BioELN and GraphPad Prism for data analysis