Senior Scientist, In Vivo Cardiovascular Disease

Job Description

The Cardiometabolic Disease (CMD) department at our Company Research Labs South San Francisco is seeking an innovative and highly motivated Senior Scientist to join our team. The prospective candidate will be working in a multidisciplinary group to identify and advance drug targets for cardiovascular diseases, and will bring scientific curiosity, an analytical mindset, a willingness to learn, and a passion for understanding disease biology and mechanism of action.

The ideal candidate will hold a Ph.D. in biology, physiology, or a related field with a strong scientific background and a proven track record of research in cardiovascular biology and associated diseases, demonstrated by peer-reviewed publications and presentations at scientific conferences.- The candidate should have extensive experience in developing in vivo preclinical models of cardiovascular disease.-The individual is expected to be a problem-solver with deep cardiovascular disease expertise, strong technical and communication skills, and has demonstrated flexibility working across in vivo and in vitro approaches.

Key Responsibilities :

• Design and execute experiments independently in the laboratory for target identification and validation utilizing in vivo preclinical models of cardiovascular disease
• Be a team-player, working productively and collaboratively in cross-functional teams within and outside of our Company Research Laboratories to advance drug targets for cardiovascular disease
• Communicate experimental results with stakeholders effectively and present research findings internally and at external scientific conferences
• Stay apprised of latest scientific advances in the field
• Learn and establish novel platforms and cutting-edge technologies to advance drug discovery efforts
• Document research activities using electronic lab notebooks and contribute to scientific publications and technical reports

Qualifications :

Education:

• Ph.D. degree in cell biology, molecular biology, physiology, or related discipline with at least one (1) year of relevant experience

Required Experience and Skills:

• Hands-on experience working with rodents and development of animal models of cardiovascular disease (e.g., heart failure, atherosclerosis, atrial fibrillation, hypertension)
• Direct involvement with efficacy readouts such as echocardiography to assess cardiac function
• Proven ability to solve complex problems by undertaking innovative approaches and applying state-of-art technologies
• Proficiency in standard molecular and cellular biology techniques, ex vivo sample processing and analysis
• Able to work independently to design and execute experiments, interpret experimental data appropriately and proficiently, and present to teams within and outside the disease area
• High level of organizational skills to support multiple projects
• Excellent oral and written communication skills, having necessary people skills, and being able to work effectively in a matrixed environment

Preferred Experience and Skills:

• Strategic thinker with in-depth knowledge of cardiovascular disease pathophysiology
• Experience in one or more of the following areas: target identification & validation, cardiovascular disease, kidney disease, inflammation or lipid metabolism
• Experience with primary cell culture models of cardiac function and cell-based assays
• Basic understanding of the translatability of animal models to human cardiovascular disease and biomarker strategies
• Strong quantitative skills, proficiency in data analysis and application of statistical methods
• Familiarity with OMICs approaches

#EligibleforERP-

Required Skills:
Animal Models, Cardiovascular Diseases, Drug Target Identification, Echocardiography, Experimental Research Design, Heart Disease, Inflammatory Diseases, In Vitro Research, In Vivo Animal Models, In Vivo Models, In Vivo Studies, Kidney Disease Treatment, Lipids, Validation

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

The salary range for this role is
$131,400.00 - $206,800.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .

You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
Not Applicable

Shift:
1st - Day

Valid Driving License:
No

Hazardous Material(s):
N/A

Job Posting End Date:
02/6/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R381486