Research Associate
Research Associate Title: Research Associate Department: ADME Department Location: Hayward, CA (on-site) Reports to : Group Leader - ADME Department Classification: Full-time About Us: Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials. Position/Job Summary: This position will support experiment design, data collection, analysis, troubleshooting, and data reporting within the ADME department. This includes gathering data on pre-clinical compound parameters using a variety of techniques, organizing and processing the data using statistical and analytical methods to reach meaningful conclusions, and reporting observations to clients and other decision-makers. Roles & Responsibilities:
- Report to the senior team leader.
- Work and collaborate daily with a group of in vitro assay biologists within the ADME department.
- Learn from and teach other group members to improve skills, increase productivity, and take part in cross-training of all ADME assays.
- Maintain a detailed laboratory notebook.
- Develop compound methods and collect data using LC-MS/MS and other modalities (HPLC, spectrophotometry, etc.)
- Conduct day-to-day testing of compounds in several cell/protein-based in vitro assays or experiments in a team-oriented environment.
- Analyze and interpret data using different software programs (Sciex Analyst, DiscoveryQuant, GraphPad prism, MS Excel, etc.)
- Prepare reports and communicate with collaborators and clients.
- Multitask, recognize problems, provide input to solutions, draft reports, and communicate results proficiently with clients and in lab meetings.
- Contribute to basic lab maintenance such as preparing buffers, cleaning, ordering, stocking, and follow-up.
- Communicate and work closely with other departments to finish collaboration projects in a timely manner.
- Offer drug discovery screening and IND filing support for multiple client-based projects
- Other duties as assigned
- BS or MS in biology, chemistry, or related area.
- 2-4 years of related experience in the biotech, pharma or preclinical CRO industry. Working experience with LC-MS/MS, HPLC, bioanalytical studies preferred.
- Strong problem solving and troubleshooting skills with demonstrated ability to resolve complex situations that require a logical, analytical and methodical approach.
- Self-motivated to multitask, initiate projects, and work both independently and in a team environment to meet deadlines
- Excellent organization and planning skills with attention to detail.
- Committed to customer satisfaction and focused on the importance of quality.
- Excellent interpersonal and communication skills.
- Hands-on exposure to general biotech laboratory equipment. A preferred candidate will have a good understanding and knowledge of laboratory tools, techniques, methods, and underlying principles. Work experience in cell-culture or in an in vitro ADME/DMPK lab preferred but not required.
- A theoretical understanding of different ADME assays (solubility, microsomal stability, plasma and blood stability, plasma protein binding, permeability, CYP enzyme and transporter inhibition and substrate determination, etc.) preferred but not required.
- May work with potentially infectious samples of human and/or animal origin (i.e. blood, tissues, etc.).
- May handle hazardous chemicals.
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