Sr Mgr, G&A Applications Business Partner

Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values, Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome, we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible.

Position Overview

Kyverna Therapeutics is seeking an experienced Sr Mgr, G&A Applications Business Partner to join its Information Technology organization. This role will serve as a strategic and operational partner to Finance, Accounting, Legal, HR, and Commercial functions, ensuring that enterprise systems are scalable, compliant, and aligned with

business objectives in a regulated biotech environment.

Reports To: Dir, Business Applications

Location: Emeryville, CA (Hybrid – onsite two days per week)

Responsibilities

• Own the strategy, delivery, and ongoing optimization of Finance, Accounting, Legal, HR, and Commercial systems to support business growth, operational efficiency, and regulatory compliance.
• Document, analyze, and continuously improve end-to-end business processes and workflows, identifying opportunities for automation and reduction of manual activities.
• Partner closely with functional leaders to understand business needs and translate them into system solutions, including development of business cases, cost-benefit analyses, and ROI assessments for new implementations or enhancements.
• Lead the full system lifecycle from intake and vendor selection through implementation, validation, go-live, and post-launch support, including requirements gathering, configuration, SOX validation, testing, training, and stabilization.
• Establish and manage change control processes and lead system upgrades, patches, and enhancements to ensure system reliability, security, and compliance.
• Champion IT governance by driving consistent application of policies, procedures, and best practices across all G&A systems.
• Ensure the accuracy, completeness, and integrity of SOX-relevant data through system controls, audits, and reconciliations.
• Develop and deliver dashboards, reports, and analytics that provide leadership with clear insights into business performance, system health, and operational KPIs.
• Ensure all supported systems comply with applicable regulatory and privacy requirements, including FDA regulations, GDPR, and other biotech and life sciences standards.
• Develop, maintain, and audit system validation and SOX documentation.
• Implement and enforce security controls to protect sensitive information, including patient data, employee records, and proprietary research.
• Act as an escalation point and hands-on problem solver for critical G&A system issues, balancing strategic leadership with operational execution.
• Collaborate with IT leadership and business stakeholders to define and maintain a cross-functional G&A systems roadmap aligned with corporate priorities.

Qualifications

• Bachelor’s degree in Business, Information Technology, Computer Science, Finance, or a related discipline; MBA or MS preferred.
• 10+ years of experience in a Business Systems Analyst, IT Business Partner, or similar role, ideally within biotech, life sciences, or a public company environment.
• Proven experience supporting Finance, Accounting, Legal, HR, and Commercial systems such as ERP, P2P, ADP, CLM, CRM, and related platforms.
• Strong understanding of system integrations, configuration, testing, and SOX-compliant system support.
• Demonstrated expertise in compliance requirements, including Sarbanes-Oxley, FDA regulations, Sunshine Act, HIPAA, and GDPR.
• Advanced analytical and problem-solving skills, with the ability to perform gap analysis, gather requirements, and design scalable, efficient solutions.
• Strong technical acumen, including experience with SQL, data analytics, and reporting tools such as Power BI.
• Ability to translate complex business needs into clear technical requirements and system designs.
• Solid understanding of the drug development lifecycle and foundational principles of cell and gene therapy.
• Proven process improvement mindset with a track record of driving efficiencies across enterprise systems.
• Strong project management capabilities, with the ability to manage multiple initiatives concurrently.
• Excellent communication and interpersonal skills, with the ability to influence and collaborate effectively with senior leadership and cross-functional stakeholders.
• Highly organized, detail-oriented, and customer-focused, with a proactive approach to issue resolution and continuous improvement.

The national salary range for this position is $165,000 to $185,000 USD annually. The final compensation will be based on individual qualifications, experience, skills, internal equity, and market alignment. This position is also eligible for an annual bonus, comprehensive benefits, and participation in the Company’s stock option plan.